Ontology highlight
ABSTRACT:
SUBMITTER: Brodowska K
PROVIDER: S-EPMC4135181 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Brodowska Katarzyna K Al-Moujahed Ahmad A Marmalidou Anna A Meyer Zu Horste Melissa M Cichy Joanna J Miller Joan W JW Gragoudas Evangelos E Vavvas Demetrios G DG
Experimental eye research 20140515
Verteporfin (VP), a benzoporphyrin derivative, is clinically used in photodynamic therapy for neovascular macular degeneration. Recent studies indicate that VP may inhibit growth of hepatoma cells without photoactivation through inhibition of YAP-TEAD complex. In this study, we examined the effects of VP without light activation on human retinoblastoma cell lines. Verteporfin but not vehicle control inhibited the growth, proliferation and viability of human retinoblastoma cell lines (Y79 and WER ...[more]