Feasibility study of a bio-inspired artificial pancreas in adults with type 1 diabetes.

ABSTRACT:

Background

This study assesses proof of concept and safety of a novel bio-inspired artificial pancreas (BiAP) system in adults with type 1 diabetes during fasting, overnight, and postprandial conditions. In contrast to existing glucose controllers in artificial pancreas systems, the BiAP uses a control algorithm based on a mathematical model of β-cell physiology. The algorithm is implemented on a miniature silicon microchip within a portable hand-held device that interfaces the components of the artificial pancreas.

Materials and methods

In this nonrandomized open-label study each subject attended for a 6-h fasting study followed by a 13-h overnight and post-breakfast study on a separate occasion. During both study sessions the BiAP system was used, and microboluses of insul

SUBMITTER: Reddy M 

PROVIDER: S-EPMC4135321 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature