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Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

ABSTRACT: We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200?mg or zonisamide 400?mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n?=?53), zonisamide 200?mg (n?=?49) and zonisamide 400?mg groups (n?=?52) were 0.5?kg [95% confidence interval (CI), -0.8 to 1.8; 0.7%], 1.5?kg (0.2-2.8; 1.6%; p?=?0.26 vs. placebo) and 2.4?kg (1.1-3.7; 2.6%; p?=?0.04 vs. placebo), respectively. Our results suggest that although zonisamide 400?mg daily for 12-months resulted in greater weight loss than with placebo, weight regain after discontinuation of interventions was greater in the zonisamide 400?mg group than placebo group.

SUBMITTER: Shin JH

PROVIDER: S-EPMC4135527 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

Shin J H JH Gadde K M KM Østbye T T Bray G A GA

Diabetes, obesity & metabolism 20140310 8

We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200 mg or zonisamide 400 mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n = 53), zonis ...[more]

PMID: 25123600

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Project description:BackgroundDespite the growing recognition of the obesity crisis, its rates continue to rise. The current first-line therapies, such as dietary changes, energy restriction, and physical activity, are typically met with poor adherence. Novel nutritional interventions can address the root causes of obesity, including mitochondrial dysfunction, and facilitate weight loss.ObjectiveThe objective of this study was to investigate the effects of a multi-ingredient nutritional supplement designed to facilitate mitochondrial function and metabolic health outcomes over a 12 wk period.MethodsFifty-five overweight and/or obese participants (age (mean ± SEM): 26 ± 1; body mass index (BMI) (kg/m2): 30.5 ± 0.6) completed this double-blind, placebo-controlled clinical trial. Participants were randomized to 12 wks of daily consumption of multi-ingredient supplement (MIS; n = 28; containing 50 mg forskolin, 500 mg green coffee bean extract, 500 mg green tea extract, 500 mg beet root extract, 400 mg α-lipoic acid, 200 IU vitamin E, and 200 mg CoQ10) or control placebo (PLA, n = 27; containing microcrystalline cellulose) matched in appearance. The co-primary outcomes were bodyweight and fat mass (kg) changes. The secondary outcomes included other body composition measures, plasma markers of obesity, fatty liver disease biomarkers, resting energy metabolism, blood pressure, physical performance, and quality of life. The post-intervention differences between MIS and PLA were examined via ANCOVA which was adjusted for the respective pre-intervention variables.ResultsAfter adjustment for pre-intervention data, there was a significant difference in weight (p < 0.001) and fat mass (p < 0.001) post-intervention between the PLA and MIS treatment arms. Post-intervention weight and fat mass were significantly lower in MIS. Significant post-intervention differences corrected for baseline were found in markers of clinical biochemistry (AST, p = 0.017; ALT, p = 0.008), molecular metabolism (GDF15, p = 0.028), and extracellular vesicle-associated miRNA species miR-122 and miR-34a in MIS (p < 0.05).ConclusionsFollowing the 12 wks of MIS supplementation, weight and body composition significantly improved, concomitant with improvements in molecular markers of liver health and metabolism.

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Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

Publications

Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

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