Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

ABSTRACT: We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200?mg or zonisamide 400?mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n?=?53), zonisamide 200?mg (n?=?49) and zonisamide 400?mg groups (n?=?52) were 0.5?kg [95% confidence interval (CI), -0.8 to 1.8; 0.7%], 1.5?kg (0.2-2.8; 1.6%; p?=?0.26 vs. placebo) and 2.4?kg (1.1-3.7; 2.6%; p?=?0.04 vs. placebo), respectively. Our results suggest that although zonisamide 400?mg daily for 12-months resulted in greater weight loss than with placebo, weight regain after discontinuation of interventions was greater in the zonisamide 400?mg group than placebo group.

SUBMITTER: Shin JH 

PROVIDER: S-EPMC4135527 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature