Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Q
PROVIDER: S-EPMC4135571 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Cheng Qian Q Song Tanjing T Chen Lihong L Chen Jiandong J
Molecular and cellular biology 20140519 15
The RING domain ubiquitin E3 ligase MDM2 is a key regulator of p53 degradation and a mediator of signals that stabilize p53. The current understanding of the mechanisms by which MDM2 posttranslational modifications and protein binding cause p53 stabilization remains incomplete. Here we present evidence that the MDM2 central acidic region is critical for activating RING domain E3 ligase activity. A 30-amino-acid minimal region of the acidic domain binds to the RING domain through intramolecular i ...[more]