Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Garcia V
PROVIDER: S-EPMC4135622 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20140623 18
The phosphoinositide 3-kinase (PI3K)/PTEN (phosphatase and tensin homolog) pathway is one of the central routes that enhances cell survival, division, and migration, and it is frequently deregulated in cancer. PI3K catalyzes formation of phosphatidylinositol 3,4,5-triphosphate [PI(3,4,5)P3] after cell activation; PTEN subsequently reduces these lipids to basal levels. Activation of the ubiquitous p110α isoform precedes that of p110β at several points during the cell cycle. We studied the potenti ...[more]