Ontology highlight
ABSTRACT:
SUBMITTER: El-Mowafi SA
PROVIDER: S-EPMC4135888 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
El-Mowafi Shaima A SA Alumasa John N JN Ades Sarah E SE Keiler Kenneth C KC
Antimicrobial agents and chemotherapy 20140707 9
Noncoding small RNAs (sRNAs) act in conjunction with the RNA chaperone Hfq to regulate gene expression in bacteria. Because Hfq is required for virulence in several bacterial pathogens, the Hfq-sRNA system is an attractive target for antibiotic development. A reporter strain in which the expression of yellow fluorescent protein (YFP) is controlled by Hfq-sRNA was engineered to identify inhibitors of this system. A reporter that is targeted by Hfq in conjunction with the RybB sRNA was used in a g ...[more]