Ontology highlight
ABSTRACT:
SUBMITTER: Krammer F
PROVIDER: S-EPMC4135918 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Krammer Florian F Jul-Larsen Asne A Margine Irina I Hirsh Ariana A Sjursen Haakon H Zambon Maria M Cox Rebecca J RJ
Clinical and vaccine immunology : CVI 20140618 8
Emerging H7N9 influenza virus infections in Asia have once more spurred the development of effective prepandemic H7 vaccines. However, many vaccines based on avian influenza viruses--including H7--are poorly immunogenic, as measured by traditional correlates of protection. Here we reevaluated sera from an H7N1 human vaccine trial performed in 2006. We examined cross-reactive antibody responses to divergent H7 strains, including H7N9, dissected the antibody response into head- and stalk-reactive ...[more]