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Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

ABSTRACT: Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.

SUBMITTER: Moura I

PROVIDER: S-EPMC4135993 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Moura Ines I Monot Marc M Tani Chiara C Spigaglia Patrizia P Barbanti Fabrizio F Norais Nathalie N Dupuy Bruno B Bouza Emilio E Mastrantonio Paola P

Antimicrobial agents and chemotherapy 20140609 8

Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress. ...[more]

PMID: 24913157

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