Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia.
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ABSTRACT:
SUBMITTER: Burd EM
PROVIDER: S-EPMC4136127 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia.
Burd Eileen M EM Alam Mohammad Tauqeer MT Passalacqua Karla D KD Kalokhe Ameeta S AS Eaton Molly E ME Satola Sarah W SW Kraft Colleen S CS Read Timothy D TD
Journal of clinical microbiology 20140521 8
Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates. ...[more]
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