Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.
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ABSTRACT:
SUBMITTER: Crispin M
PROVIDER: S-EPMC4136308 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.
Crispin Max M Harvey David J DJ Bitto David D Halldorsson Steinar S Bonomelli Camille C Edgeworth Matthew M Scrivens James H JH Huiskonen Juha T JT Bowden Thomas A TA
Journal of virology 20140618 17
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave ...[more]
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