Ontology highlight
ABSTRACT:
SUBMITTER: Ganem NJ
PROVIDER: S-EPMC4136486 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ganem Neil J NJ Cornils Hauke H Chiu Shang-Yi SY O'Rourke Kevin P KP Arnaud Jonathan J Yimlamai Dean D Théry Manuel M Camargo Fernando D FD Pellman David D
Cell 20140801 4
Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ∼37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the cellular defects and corresponding signaling pathways that trigger growth suppression in tetraploid cells are not known. Here, we combine RNAi screening and in vitro evolution approaches to demonstra ...[more]