Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4136581 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhang Yuyuan Y Dood Jordan J Beckstead Ashley A AA Li Xi-Bo XB Nguyen Khiem V KV Burrows Cynthia J CJ Improta Roberto R Kohler Bern B
Proceedings of the National Academy of Sciences of the United States of America 20140728 32
During the early evolution of life, 8-oxo-7,8-dihydro-2'-deoxyguanosine (O) may have functioned as a proto-flavin capable of repairing cyclobutane pyrimidine dimers in DNA or RNA by photoinduced electron transfer using longer wavelength UVB radiation. To investigate the ability of O to act as an excited-state electron donor, a dinucleotide mimic of the FADH2 cofactor containing O at the 5'-end and 2'-deoxyadenosine at the 3'-end was studied by femtosecond transient absorption spectroscopy in aqu ...[more]