Ontology highlight
ABSTRACT:
SUBMITTER: Hojyo S
PROVIDER: S-EPMC4136588 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Hojyo Shintaro S Miyai Tomohiro T Fujishiro Hitomi H Kawamura Masami M Yasuda Takuwa T Hijikata Atsushi A Bin Bum-Ho BH Irié Tarou T Tanaka Junichi J Atsumi Toru T Murakami Masaaki M Nakayama Manabu M Ohara Osamu O Himeno Seiichiro S Yoshida Hisahiro H Koseki Haruhiko H Ikawa Tomokatsu T Mishima Kenji K Fukada Toshiyuki T
Proceedings of the National Academy of Sciences of the United States of America 20140729 32
The humoral immune response, also called the antibody-mediated immune response, is one of the main adaptive immune systems. The essential micronutrient zinc (Zn) is known to modulate adaptive immune responses, and dysregulated Zn homeostasis leads to immunodeficiency. However, the molecular mechanisms underlying this Zn-mediated modulation are largely unknown. Here, we show that the Zn transporter SLC39A10/ZIP10 plays an important role in B-cell antigen receptor (BCR) signal transduction. Zip10- ...[more]