Ontology highlight
ABSTRACT:
SUBMITTER: Friggeri L
PROVIDER: S-EPMC4136671 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Friggeri Laura L Hargrove Tatiana Y TY Rachakonda Girish G Williams Amanda D AD Wawrzak Zdzislaw Z Di Santo Roberto R De Vita Daniela D Waterman Michael R MR Tortorella Silvano S Villalta Fernando F Lepesheva Galina I GI
Journal of medicinal chemistry 20140729 15
Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global, becoming a new worldwide challenge with no cure available. The disease is caused by the protozoan parasite Trypanosoma cruzi, which depends on the production of endogenous sterols, and therefore can be blocked by sterol 14α-demethylase (CYP51) inhibitors. Here we explore the spectral binding parameters, inhibitory effects on T. cruzi CYP51 activity, and antiparasitic potencies of a new ...[more]