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Oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry.

ABSTRACT: The synthesis of novel oxetanyl peptides, where the amide bond is replaced by a non-hydrolyzable oxetanylamine fragment, is reported. This new class of pseudo-dipeptides with the same H-bond donor/acceptor pattern found in proteins expands the repertoire of peptidomimetics.

SUBMITTER: McLaughlin M

PROVIDER: S-EPMC4136677 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry.

McLaughlin Martin M Yazaki Ryo R Fessard Thomas C TC Carreira Erick M EM

Organic letters 20140728 16

The synthesis of novel oxetanyl peptides, where the amide bond is replaced by a non-hydrolyzable oxetanylamine fragment, is reported. This new class of pseudo-dipeptides with the same H-bond donor/acceptor pattern found in proteins expands the repertoire of peptidomimetics. ...[more]

PMID: 25068485

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