Ontology highlight
ABSTRACT:
SUBMITTER: Ma A
PROVIDER: S-EPMC4136711 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ma Anqi A Yu Wenyu W Li Fengling F Bleich Rachel M RM Herold J Martin JM Butler Kyle V KV Norris Jacqueline L JL Korboukh Victoria V Tripathy Ashutosh A Janzen William P WP Arrowsmith Cheryl H CH Frye Stephen V SV Vedadi Masoud M Brown Peter J PJ Jin Jian J
Journal of medicinal chemistry 20140725 15
The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response. In addition to H4K20, SETD8 monomethylates non-histone substrates including proliferating cell nuclear antigen (PCNA) and promotes carcinogenesis by deregulating PCNA expression. However, selective inhibitors of SETD8 are scarce. The only kno ...[more]