Ontology highlight
ABSTRACT:
SUBMITTER: Zeng LF
PROVIDER: S-EPMC4136714 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20140728 15
The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase associated with various kinds of leukemia and solid tumors. Thus, there is substantial interest in developing SHP2 inhibitors as potential anticancer and antileukemia agents. Using a structure-guided and fragment-based library approach, we identified a novel hydroxyindole carboxylic acid-based SHP2 inhibitor 11a-1, with an IC50 value of 200 nM and greater than 5-fold selectivity against 20 mamm ...[more]