Unknown

Dataset Information

0

Copy number variation analysis on a non-Hodgkin lymphoma case-control study identifies an 11q25 duplication associated with diffuse large B-cell lymphoma.


ABSTRACT: Recent GWAS have identified several susceptibility loci for NHL. Despite these successes, much of the heritable variation in NHL risk remains to be explained. Common copy-number variants are important genomic sources of variability, and hence a potential source to explain part of this missing heritability. In this study, we carried out a CNV analysis using GWAS data from 681 NHL cases and 749 controls to explore the relationship between common structural variation and lymphoma susceptibility. Here we found a novel association with diffuse large B-cell lymphoma (DLBCL) risk involving a partial duplication of the C-terminus region of the LOC283177 long non-coding RNA that was further confirmed by quantitative PCR. For chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), known somatic deletions were identified on chromosomes 13q14, 11q22-23, 14q32 and 22q11.22. Our study shows that GWAS data can be used to identify germline CNVs associated with disease risk for DLBCL and somatic CNVs for CLL/SLL.

SUBMITTER: Conde L 

PROVIDER: S-EPMC4136881 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

altmetric image

Publications

Copy number variation analysis on a non-Hodgkin lymphoma case-control study identifies an 11q25 duplication associated with diffuse large B-cell lymphoma.

Conde Lucia L   Riby Jacques J   Zhang Jianqing J   Bracci Paige M PM   Skibola Christine F CF  

PloS one 20140818 8


Recent GWAS have identified several susceptibility loci for NHL. Despite these successes, much of the heritable variation in NHL risk remains to be explained. Common copy-number variants are important genomic sources of variability, and hence a potential source to explain part of this missing heritability. In this study, we carried out a CNV analysis using GWAS data from 681 NHL cases and 749 controls to explore the relationship between common structural variation and lymphoma susceptibility. He  ...[more]

Similar Datasets

2014-09-23 | GSE58718 | GEO
2014-09-23 | E-GEOD-58718 | biostudies-arrayexpress
| S-EPMC2574762 | biostudies-literature
2016-01-22 | GSE71394 | GEO
2008-05-10 | GSE11369 | GEO
2016-01-22 | GSE71386 | GEO
| S-EPMC3837631 | biostudies-literature
| S-EPMC2922892 | biostudies-other
2019-10-24 | GSE136962 | GEO
2008-05-10 | E-GEOD-11369 | biostudies-arrayexpress