Ontology highlight
ABSTRACT:
SUBMITTER: Edens LJ
PROVIDER: S-EPMC4137061 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Edens Lisa J LJ Levy Daniel L DL
The Journal of cell biology 20140801 4
Dramatic changes in cell and nuclear size occur during development and differentiation, and aberrant nuclear size is associated with many disease states. However, the mechanisms that regulate nuclear size are largely unknown. A robust system for investigating nuclear size is early Xenopus laevis development, during which reductions in nuclear size occur without changes in DNA content. To identify cellular factors that regulate nuclear size during development, we developed a novel nuclear resizin ...[more]