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Palladium catalyzed intramolecular acylcyanation of alkenes using ?-iminonitriles.

ABSTRACT: Reported here is a palladium catalyzed intramolecular acylcyanation of alkenes using ?-iminonitriles. Through this method, highly functionalized indanones are synthesized in moderate to high yields using Pd(PPh3)4, without need for any additional ligands, and a common Lewis acid (ZnCl2). Additionally, the reaction tolerates substitution at various positions on the aromatic ring including electron donating and electron withdrawing groups.

SUBMITTER: Rondla NR 

PROVIDER: S-EPMC4137412 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles.

Rondla Naveen R NR   Ogilvie Jodi M JM   Pan Zhongda Z   Douglas Christopher J CJ  

Chemical communications (Cambridge, England) 20140801 64

Reported here is a palladium catalyzed intramolecular acylcyanation of alkenes using α-iminonitriles. Through this method, highly functionalized indanones are synthesized in moderate to high yields using Pd(PPh3)4, without need for any additional ligands, and a common Lewis acid (ZnCl2). Additionally, the reaction tolerates substitution at various positions on the aromatic ring including electron donating and electron withdrawing groups. ...[more]

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