Ontology highlight
ABSTRACT:
SUBMITTER: Lowe DA
PROVIDER: S-EPMC4137566 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Lowe Dylan A DA Lepori-Bui Nadia N Fomin Peter V PV Sloofman Laura G LG Zhou Xiaozhou X Farach-Carson Mary C MC Wang Liyun L Kirn-Safran Catherine B CB
Calcified tissue international 20140506 1
Perlecan/HSPG2 (Pln) is a large heparan sulfate proteoglycan abundant in the extracellular matrix of cartilage and the lacunocanalicular space of adult bones. Although Pln function during cartilage development is critical, evidenced by deficiency disorders including Schwartz-Jampel Syndrome and dyssegmental dysplasia Silverman-Handmaker type, little is known about its function in development of bone shape and quality. The purpose of this study was to understand the contribution of Pln to bone ge ...[more]