Pharmacologic therapy for pulmonary arterial hypertension in adults: CHEST guideline and expert panel report.
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ABSTRACT: Objective
Choices of pharmacologic therapies for pulmonary arterial hypertension (PAH) are ideally guided by high-level evidence. The objective of this guideline is to provide clinicians advice regarding pharmacologic therapy for adult patients with PAH as informed by available evidence.Methods
This guideline was based on systematic reviews of English language evidence published between 1990 and November 2013, identified using the MEDLINE and Cochrane Library databases. The strength of available evidence was graded using the Grades of Recommendations, Assessment, Development, and Evaluation methodology. Guideline recommendations, or consensus statements when available evidence was insufficient to support recommendations, were developed using a modified Delphi technique to achieve consensus.Results
Available evidence is limited in its ability to support high-level recommendations. Therefore, we drafted consensus statements to address many clinical questions regarding pharmacotherapy for patients with PAH. A total of 79 recommendations or consensus statements were adopted and graded.Conclusions
Clinical decisions regarding pharmacotherapy for PAH should be guided by high-level recommendations when sufficient evidence is available. Absent higher level evidence, consensus statements based upon available information must be used. Further studies are needed to address the gaps in available knowledge regarding optimal pharmacotherapy for PAH.
SUBMITTER: Taichman DB
PROVIDER: S-EPMC4137591 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Pharmacologic therapy for pulmonary arterial hypertension in adults: CHEST guideline and expert panel report.
Taichman Darren B DB Ornelas Joe J Chung Lorinda L Klinger James R JR Lewis Sandra S Mandel Jess J Palevsky Harold I HI Rich Stuart S Sood Namita N Rosenzweig Erika B EB Trow Terence K TK Yung Rex R Elliott C Gregory CG Badesch David B DB
Chest 20140801 2
<h4>Objective</h4>Choices of pharmacologic therapies for pulmonary arterial hypertension (PAH) are ideally guided by high-level evidence. The objective of this guideline is to provide clinicians advice regarding pharmacologic therapy for adult patients with PAH as informed by available evidence.<h4>Methods</h4>This guideline was based on systematic reviews of English language evidence published between 1990 and November 2013, identified using the MEDLINE and Cochrane Library databases. The stren ...[more]
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