Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells.
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ABSTRACT:
SUBMITTER: Xie Y
PROVIDER: S-EPMC4138271 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
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Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells.
Xie Yucai Y Ibrahim Ahmed A Cheng Ke K Wu Zhijun Z Liang Wenbin W Malliaras Konstantinos K Sun Baiming B Liu Weixin W Shen Deliang D Cheol Cho Hee H Li Taosheng T Lu Lin L Lu Guoping G Marbán Eduardo E
Stem cells (Dayton, Ohio) 20140901 9
Cardiosphere-derived cells (CDCs) effect therapeutic regeneration after myocardial infarction (MI) both in animal models and in humans. Here, we test the hypothesis that cell-cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects. Human CDCs or vehicle were injected into immunodeficient (SCID) mouse hearts during acute MI. CDC transplantation augmented the proportion of cycling (Ki67(+) ) cardiomyocytes and improved ventr ...[more]
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Project description:The clinical reality of cell therapy for heart disease dates back to the 1990 s, when autologous skeletal myoblasts were first transplanted into failing hearts during open-chest surgery. Since then, the focus has shifted to bone marrow-derived cells and, more recently, cells extracted from the heart itself. Although progress has been nonlinear and often disheartening, the field has nevertheless made remarkable progress. Six major breakthroughs are notable: (1) the establishment of safety with intracoronary delivery; (2) the finding that therapeutic regeneration is possible; (3) the increase in allogeneic cell therapy; (4) the effect of increasing mechanistic insights; (5) glimmers of clinical efficacy; and (6) the progression to phase 2 and 3 studies. This article individually reviews these landmark developments in detail and concludes that the field has reached a new phase of maturity where the prospect of clinical impact is increasingly imminent.
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