Ontology highlight
ABSTRACT:
SUBMITTER: Krishnamurty R
PROVIDER: S-EPMC4138815 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Krishnamurty Ratika R Brock Amanda M AM Maly Dustin J DJ
Bioorganic & medicinal chemistry letters 20101021 1
Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures. ...[more]