Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC4138828 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhang Shiyi S Zou Jiong J Elsabahy Mahmoud M Karwa Amolkumar A Li Ang A Moore Dennis A DA Dorshow Richard B RB Wooley Karen L KL
Chemical science 20130101 5
A new type of degradable, nanoscopic polymer assembly containing ultra-high levels of drug loading <i>via</i> covalent attachment within amphiphilic core-shell nanoparticle morphology has been generated as a potentially effective and safe anti-cancer agent. Poly(ethylene oxide)-<i>block</i>-polyphosphoester-based paclitaxel drug conjugates (PEO-<i>b</i>-PPE-<i>g</i>-PTX) were synthesized by rapid, scalable and versatile approach that involves only two steps: organocatalyst-promoted ring-opening- ...[more]