Ontology highlight
ABSTRACT:
SUBMITTER: Johnson ZL
PROVIDER: S-EPMC4139061 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Johnson Zachary Lee ZL Lee Jun-Ho JH Lee Kiyoun K Lee Minhee M Kwon Do-Yeon DY Hong Jiyong J Lee Seok-Yong SY
eLife 20140731
Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents. Understanding how CNTs recognize and import their substrates could not only lead to a better understanding of nucleoside-related biological processes but also the design of nucleoside-derived drugs that can better ...[more]