Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC4139111 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Liu Huisheng H Bai Hua H Xue Renhao R Takahashi Hirohide H Edwardson J Michael JM Chapman Edwin R ER
Nature neuroscience 20140323 5
The Ca(2+) sensor for rapid synaptic vesicle exocytosis, synaptotagmin 1 (syt), is largely composed of two Ca(2+)-sensing C2 domains, C2A and C2B. We investigated the apparent synergy between the tandem C2 domains by altering the length and rigidity of the linker that connects them. The behavior of the linker mutants revealed a correlation between the ability of the C2 domains to penetrate membranes in response to Ca(2+) and to drive evoked neurotransmitter release in cultured mouse neurons, unc ...[more]