CASPASE-12 and rheumatoid arthritis in African-Americans.
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ABSTRACT:
SUBMITTER: Marshall L
PROVIDER: S-EPMC4139147 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
CASPASE-12 and rheumatoid arthritis in African-Americans.
Marshall Laura L Obaidullah Mohammad M Fuchs Trista T Fineberg Naomi S NS Brinkley Garland G Mikuls Ted R TR Bridges S Louis SL Hermel Evan E
Immunogenetics 20140211 4
CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal-Wallis non-parametric ANOVA with Mann-Whitney U tests and chi-square tests. There was no significant difference in the ...[more]
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