Ontology highlight
ABSTRACT:
SUBMITTER: Ptak CP
PROVIDER: S-EPMC4139157 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ptak Christopher P CP Hsieh Ching-Lin CL Hsieh Ching-Lin CL Lin Yi-Pin YP Maltsev Alexander S AS Raman Rajeev R Sharma Yogendra Y Oswald Robert E RE Chang Yung-Fu YF
Biochemistry 20140804 32
A number of surface proteins specific to pathogenic strains of Leptospira have been identified. The Lig protein family has shown promise as a marker in typing leptospiral isolates for pathogenesis and as an antigen in vaccines. We used NMR spectroscopy to solve the solution structure of the twelfth immunoglobulin-like (Ig-like) repeat domain from LigB (LigB-12). The fold is similar to that of other bacterial Ig-like domains and comprised mainly of β-strands that form a β-sandwich based on a Gree ...[more]