Ontology highlight
ABSTRACT:
SUBMITTER: Spencer AJ
PROVIDER: S-EPMC4139357 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Spencer Alexandra J AJ Furze Julie J Honeycutt Jared D JD Calvert Alice A Saurya Saroj S Colloca Stefano S Wyllie David H DH Gilbert Sarah C SC Bregu Migena M Cottingham Matthew G MG Hill Adrian V S AV
PloS one 20140820 8
T cells play a central role in the immune response to many of the world's major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to increase T cell immunogenicity induced by a variety of recombinant vectored vaccines. To efficiently test this hypothesis, we assessed a number of promoters and developed a stable bi-cistronic vector expressing both the antigen and adjuvant. Co-expressi ...[more]