The evolution of enzyme function in the isomerases.
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ABSTRACT:
SUBMITTER: Martinez Cuesta S
PROVIDER: S-EPMC4139412 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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The evolution of enzyme function in the isomerases.
Martinez Cuesta Sergio S Furnham Nicholas N Rahman Syed Asad SA Sillitoe Ian I Thornton Janet M JM
Current opinion in structural biology 20140601
The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar. ...[more]
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