Analgesia dose prescribing and estimated glomerular filtration rate decline: a general practice database linkage cohort study.

ABSTRACT:

Objective

We aimed to quantify the short-term effect of non-steroidal anti-inflammatory drugs (NSAIDs), aspirin and paracetamol analgesia dose prescribing on estimated glomerular filtration rate (eGFR) decline in the general practice population.

Design

A population-based longitudinal clinical data linkage cohort study.

Setting

Two large general practices in North Staffordshire, UK.

Participants

Patients aged 40?years and over with ?2 eGFR measurements spaced ?90?days apart between 1 January 2009 and 31 December 2010 were selected.

Exposure

Using WHO Defined Daily Dose standardised cumulative analgesia prescribing, patients were categorised into non-user, normal and high-dose groups.

Outcome measure

The primary outcome was defined as a >5?mL/min/1.73?m(2)/year eGFR decrease between the first and last eGFR. Logistic regression analyses were used to estimate risk, adjusting for sociodemographics, comorbidity, baseline chronic kidney disease (CKD) status, renin-angiotensin-system inhibitors and other analgesia prescribing.

Results

There were 4145 patients (mean age 66?years, 55% female) with an analgesia prescribing prevalence of 17.2% for NSAIDs, 39% for aspirin and 22% for paracetamol and stage 3-5 CKD prevalence was 16.1% (n=667). Normal or high-dose NSAID and paracetamol prescribing was not significantly associated with eGFR decline. High-dose aspirin prescribing was associated with a reduced risk of eGFR decline in patients with a baseline (first) eGFR ?60?mL/min/1.73?m(2); OR=0.52 (95% CI 0.35 to 0.77).

Conclusions

NSAID, aspirin and paracetamol prescribing over 2?years did not significantly affect eGFR decline with a reduced risk of eGFR decline in high-dose aspirin users with well-preserved renal function. However, the long-term effects of analgesia use on eGFR decline remain to be determined.

SUBMITTER: Nderitu P 

PROVIDER: S-EPMC4139623 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature