Dataset Information

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

ABSTRACT:

Objectives

To propose a feasible suggestion to reduce the high prevalence of anaemia in middle-aged and elderly women by investigating risk factors, particularly nutritional factors, and analysing the effect on anaemia in three different rural areas of China.

Design

A case-control study.

Setting

Three counties of China.

Participants

Women aged 50-75?years in the three counties.

Main outcome measures

Adjusted OR (95% CI) of anaemia associated with diet, lifestyle and blood biochemical indices.

Results

Compared with controls, women with anaemia had lower body mass index (22.1 (3.2) kg/m(2) vs 23.2 (3.5)?kg/m(2); p<0.001), a higher experience of shortage of food (45.0% vs 36.5%; p<0.001), less soy food intake (0.5 (0.3, 26.7)?g/day vs 5.6 (0.4, 27.8)?g/day; p<0.048), lower serum iron (13.4 (5.4)??mol/L vs 16.4 (5.7)??mol/L; p<0.001), lower ferritin (109.6 (85.6)?ng/mL vs 131.0 (92.0)?ng/mL; p<0.001), lower transferrin saturation levels (22.5 (9.5)% vs 26.8 (9.6)%; p<0.001) and higher levels of free erythrocyte protoporphyrin (42.4 (21.2)??g/dL vs 39.6 (17.8)??g/dL; p<0.001). Anaemia was significantly associated with BMI(OR=0.90, 95% CI (0.87 to 0.92)), food shortage experience (OR=1.39, 95% CI (1.15 to 1.69)), total protein (OR=0.66, 95%CI (0.54 to 0.80)), Albumin (OR=0.72, 95%CI (0.59 to 0.87)) in univariate analysis. Multivariate analysis showed that body mass index, experience of food shortage, total protein and albumin were independently related to anaemia.

Conclusions

Among middle-aged and elderly women in rural China, the nutrition status of anaemic cases is far below that of controls. Lower body mass index and a greater experience of food shortage are closely related to anaemia. Improving the blood protein status by consuming protein-sufficient foods such as soy food is a feasible approach for elderly anaemic women. Further research is needed on the effect of chronic inflammation and infectious disease on anaemia in elderly women in rural China.

SUBMITTER: Song P

PROVIDER: S-EPMC4139636 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

Song Pengkun P Li Lixiang L Man Qingqing Q Wang Chunrong C Meng Liping L Zhang Jian J

BMJ open 20140818 8

<h4>Objectives</h4>To propose a feasible suggestion to reduce the high prevalence of anaemia in middle-aged and elderly women by investigating risk factors, particularly nutritional factors, and analysing the effect on anaemia in three different rural areas of China.<h4>Design</h4>A case-control study.<h4>Setting</h4>Three counties of China.<h4>Participants</h4>Women aged 50-75 years in the three counties.<h4>Main outcome measures</h4>Adjusted OR (95% CI) of anaemia associated with diet, lifesty ...[more]

PMID: 25138800

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Project description:Objective: Postmenopausal osteoporosis (PMOP), a chronic systemic metabolic disease prevalent in middle-aged and elderly women, heavily relies on bone mineral density (BMD) measurement as the diagnostic indicator. In this study, we investigated serum microRNAs (miRNAs) as a possible screening tool for PMOP. Methods: This investigation recruited 83 eligible participants from 795 community-dwelling postmenopausal women between June 2020 and August 2021. The miRNA expression profiles in the serum of PMOP patients were evaluated via miRNA microarray (six PMOP patients and four postmenopausal women without osteoporosis (n-PMOP) as controls). Subsequently, results were verified in independent sample sets (47 PMOP patients and 26 n-PMOP controls) using quantitative real-time PCR. In addition, the target genes and main functions of the differentially expressed miRNAs were explored by bioinformatics analysis. Results: Four highly expressed miRNAs in the serum of patients (hsa-miR-144-5p, hsa-miR-506-3p, hsa-miR-8068, and hsa-miR-6851-3p) showed acceptable disease-independent discrimination performance (area under the curve range: 0.747-0.902) in the training set and verification set, outperforming traditional bone turnover markers. Among four key miRNAs, hsa-miR-144-5p is the only one that can simultaneously predict changes in BMD in lumbar spine 1-4, total hip, and femoral neck (β = -0.265, p = 0.022; β = -0.301, p = 0.005; and β = -0.324, p = 0.003, respectively). Bioinformatics analysis suggested that the differentially expressed miRNAs were targeted mainly to YY1, VIM, and YWHAE genes, which are extensively involved in bone metabolism processes. Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR-144-5p, hsa-miR-506-3p, hsa-miR-8068, and hsa-miR-6851-3p, can be used as novel biomarkers for PMOP diagnosis independent of radiological findings and traditional bone turnover markers. Further study of these miRNAs and their target genes may provide new insights into the epigenetic regulatory mechanisms of the onset and progression of the disease.

Dataset Information

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

Objectives

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

Similar Datasets

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