Dataset Information

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

ABSTRACT:

Objectives

To propose a feasible suggestion to reduce the high prevalence of anaemia in middle-aged and elderly women by investigating risk factors, particularly nutritional factors, and analysing the effect on anaemia in three different rural areas of China.

Design

A case-control study.

Setting

Three counties of China.

Participants

Women aged 50-75?years in the three counties.

Main outcome measures

Adjusted OR (95% CI) of anaemia associated with diet, lifestyle and blood biochemical indices.

Results

Compared with controls, women with anaemia had lower body mass index (22.1 (3.2) kg/m(2) vs 23.2 (3.5)?kg/m(2); p<0.001), a higher experience of shortage of food (45.0% vs 36.5%; p<0.001), less soy food intake (0.5 (0.3, 26.7)?g/day vs 5.6 (0.4, 27.8)?g/day; p<0.048), lower serum iron (13.4 (5.4)??mol/L vs 16.4 (5.7)??mol/L; p<0.001), lower ferritin (109.6 (85.6)?ng/mL vs 131.0 (92.0)?ng/mL; p<0.001), lower transferrin saturation levels (22.5 (9.5)% vs 26.8 (9.6)%; p<0.001) and higher levels of free erythrocyte protoporphyrin (42.4 (21.2)??g/dL vs 39.6 (17.8)??g/dL; p<0.001). Anaemia was significantly associated with BMI(OR=0.90, 95% CI (0.87 to 0.92)), food shortage experience (OR=1.39, 95% CI (1.15 to 1.69)), total protein (OR=0.66, 95%CI (0.54 to 0.80)), Albumin (OR=0.72, 95%CI (0.59 to 0.87)) in univariate analysis. Multivariate analysis showed that body mass index, experience of food shortage, total protein and albumin were independently related to anaemia.

Conclusions

Among middle-aged and elderly women in rural China, the nutrition status of anaemic cases is far below that of controls. Lower body mass index and a greater experience of food shortage are closely related to anaemia. Improving the blood protein status by consuming protein-sufficient foods such as soy food is a feasible approach for elderly anaemic women. Further research is needed on the effect of chronic inflammation and infectious disease on anaemia in elderly women in rural China.

SUBMITTER: Song P

PROVIDER: S-EPMC4139636 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

Song Pengkun P Li Lixiang L Man Qingqing Q Wang Chunrong C Meng Liping L Zhang Jian J

BMJ open 20140818 8

<h4>Objectives</h4>To propose a feasible suggestion to reduce the high prevalence of anaemia in middle-aged and elderly women by investigating risk factors, particularly nutritional factors, and analysing the effect on anaemia in three different rural areas of China.<h4>Design</h4>A case-control study.<h4>Setting</h4>Three counties of China.<h4>Participants</h4>Women aged 50-75 years in the three counties.<h4>Main outcome measures</h4>Adjusted OR (95% CI) of anaemia associated with diet, lifesty ...[more]

PMID: 25138800

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Project description:The present study was conducted to investigate the possible association between gut microbes and immunity among healthy middle-aged and elderly individuals in southwest China. A total of 148 healthy adults aged ? 50 years were divided into two age groups: middle-aged group (50-59 years; n = 67, 54.13 ± 3.32) and elderly group (? 60 years; n = 81, 64.70 ± 3.93). Blood samples were collected to measure serum immune and biochemical indices. Gut microbiota compositions of the groups were characterized on the basis of faecal DNA using 16S rRNA gene sequencing.Among the detected gut microbes, the presence of Alistipes was negatively correlated with age in both groups. In the middle-aged group, age was negatively correlated with the presence of Desulfovibrio and Faecalibacterium. In the elderly group, Coprococcus was present at significantly higher levels; age was negatively correlated with the presence of Lachnobacterium, Oxalobacter and the Chao index, whereas positively correlated with the presence of Sutterella. In the middle-aged group, the presence of Bacteroidetes was positively correlated with serum immunoglobulin G (IgG) levels and the percent of CD8+ T cells and negatively correlated with the CD4+/CD8+ ratio; the presence of Firmicutes was negatively correlated with IgM levels; Bacteroidetes/Firmicutes ratio was positively correlated with IgG and IgM levels and Simpson index was negatively correlated with the percent of CD8+ T cells and positively correlated with CD4+/CD8+ ratio. In the elderly group, the presence of Verrucomicrobia (identified as genus Akkermansia) was positively correlated with IgA levels and the percent of CD8+ T cells and negatively correlated with the percent of CD4+ T cells and CD4+/CD8+ ratio; the Chao index and observed species were positively correlated with IgA levels.These results indicated that ageing could significantly correlate with the composition of gut microbiota in terms of quantity and quality. Changes in gut microbiota caused by ageing, characterized by decreased Bacteroidetes levels, might be associated with immunosenescence among healthy middle-aged and elderly people in southwest China.

Dataset Information

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

Objectives

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Case-control study of anaemia among middle-aged and elderly women in three rural areas of China.

Similar Datasets

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