Ontology highlight
ABSTRACT:
SUBMITTER: Holmes WM
PROVIDER: S-EPMC4140192 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Holmes William M WM Mannakee Brian K BK Gutenkunst Ryan N RN Serio Tricia R TR
Nature communications 20140715
Amino-terminal acetylation is among the most ubiquitous of protein modifications in eukaryotes. Although loss of N-terminal acetylation is associated with many abnormalities, the molecular basis of these effects is known for only a few cases, where acetylation of single factors has been linked to binding avidity or metabolic stability. In contrast, the impact of N-terminal acetylation for the majority of the proteome, and its combinatorial contributions to phenotypes, are unknown. Here, by study ...[more]