Widespread genetic switches and toxicity resistance proteins for fluoride.
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ABSTRACT:
SUBMITTER: Baker JL
PROVIDER: S-EPMC4140402 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Widespread genetic switches and toxicity resistance proteins for fluoride.
Baker Jenny L JL Sudarsan Narasimhan N Weinberg Zasha Z Roth Adam A Stockbridge Randy B RB Breaker Ronald R RR
Science (New York, N.Y.) 20111222 6065
Most riboswitches are metabolite-binding RNA structures located in bacterial messenger RNAs where they control gene expression. We have discovered a riboswitch class in many bacterial and archaeal species whose members are selectively triggered by fluoride but reject other small anions, including chloride. These fluoride riboswitches activate expression of genes that encode putative fluoride transporters, enzymes that are known to be inhibited by fluoride, and additional proteins of unknown func ...[more]
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