Ontology highlight
ABSTRACT:
SUBMITTER: Meng F
PROVIDER: S-EPMC4140502 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140804 32
Catalytic enantioselective multicomponent processes involving bis(pinacolato)diboron [B2(pin)2], 1,3-enynes, and aldehydes are disclosed; the resulting compounds contain a primary C-B(pin) bond, as well as alkyne- and hydroxyl-substituted tertiary carbon stereogenic centers. A critical feature is the initial enantioselective Cu-B(pin) addition to an alkyne-substituted terminal alkene. This and other key mechanistic issues have been investigated by DFT calculations. Reactions are promoted by the ...[more]