Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez-Romero A
PROVIDER: S-EPMC4140594 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
ACS chemical neuroscience 20140707 8
We have characterized the effect of triazine derivatives on neuronal nicotinic receptors expressed in Xenopus oocytes. All triazines investigated inhibit the current of α7 and α3β4 neuronal nicotinic receptors elicited by acetylcholine. The effect is concentration dependent, reversible, and noncompetitive. In contrast, some derivatives have a dual effect on α4β2 receptors, by potentiating the currents at intermediate concentration and causing inhibition at higher concentrations. Triazine derivat ...[more]