Ontology highlight
ABSTRACT:
SUBMITTER: Acharya P
PROVIDER: S-EPMC4140785 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Acharya Priyamvada P Luongo Timothy S TS Louder Mark K MK McKee Krisha K Yang Yongping Y Kwon Young Do YD Mascola John R JR Kessler Pascal P Martin Loïc L Kwong Peter D PD
Structure (London, England : 1993) 20130523 6
The interface between the HIV-1 gp120 envelope glycoprotein and the CD4 receptor contains an unusual interfacial cavity, the "Phe43 cavity", which CD4-mimetic miniproteins with nonnatural extensions can potentially utilize to enhance their neutralization of HIV-1. Here, we report cocrystal structures of HIV-1 gp120 with miniproteins M48U1 and M48U7, which insert cyclohexylmethoxy and 5-hydroxypentylmethoxy extensions, respectively, into the Phe43 cavity. Both inserts displayed flexibility and hy ...[more]