Genetic association signal near NTN4 in Tourette syndrome.
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ABSTRACT:
SUBMITTER: Paschou P
PROVIDER: S-EPMC4140987 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Genetic association signal near NTN4 in Tourette syndrome.
Paschou Peristera P Yu Dongmei D Gerber Gloria G Evans Patrick P Tsetsos Fotis F Davis Lea K LK Karagiannidis Iordanis I Chaponis Jonathan J Gamazon Eric E Mueller-Vahl Kirsten K Stuhrmann Manfred M Schloegelhofer Monika M Stamenkovic Mara M Hebebrand Johannes J Noethen Markus M Nagy Peter P Barta Csaba C Tarnok Zsanett Z Rizzo Renata R Depienne Christel C Worbe Yulia Y Hartmann Andreas A Cath Danielle C DC Budman Cathy L CL Sandor Paul P Barr Cathy C Wolanczyk Thomas T Singer Harvey H Chou I-Ching IC Grados Marco M Posthuma Danielle D Rouleau Guy A GA Aschauer Harald H Freimer Nelson B NB Pauls David L DL Cox Nancy J NJ Mathews Carol A CA Scharf Jeremiah M JM
Annals of neurology 20140721 2
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × ...[more]
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