Ontology highlight
ABSTRACT:
SUBMITTER: Janicki SC
PROVIDER: S-EPMC4141004 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Janicki S C SC Park N N Cheng R R Clark L N LN Lee J H JH Schupf N N
Dementia and geriatric cognitive disorders 20140408 3-4
<h4>Background/aims</h4>Few studies of gene variants that affect estrogen activity investigate their association with age at onset of Alzheimer's disease (AD) in women of different ethnicities. We examined the influence of ESR1 polymorphisms on age at onset of AD in a multiethnic cohort of women.<h4>Methods</h4>Among 1,436 women participating in the Washington Heights Inwood Columbia Aging Project, association with age at AD onset was assessed for 41 single-nucleotide polymorphisms (SNPs) on the ...[more]