Ontology highlight
ABSTRACT:
SUBMITTER: Salazar Gonzalez RM
PROVIDER: S-EPMC4141014 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Salazar Gonzalez Rosa Maria RM Shehata Hesham H O'Connell Michael J MJ Yang Yanfen Y Moreno-Fernandez Maria E ME Chougnet Claire A CA Aliberti Julio J
Journal of innate immunity 20140523 5
Up to a third of the world's population is infected with Toxoplasma gondii. Natural infection in humans can be life threatening during pregnancy and in immunocompromised individuals. Toll-like receptor (TLR) 11 is the mouse innate sensor that recognizes T. gondii profilin; however, in humans the TLR11 gene leads to transcription of no functional protein. Herein, by using a multiple sequence alignment phylogenetic analysis program between human and mouse species, we found that human TLR5 seems to ...[more]