Ontology highlight
ABSTRACT:
SUBMITTER: Murakami H
PROVIDER: S-EPMC4141489 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Murakami Hajime H Keeney Scott S
Cell 20140801 4
It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 physically associate with the Dbf4-dependent Cdc7 kinase (DDK) and recruit it to the replisome, where it phosphorylates the DSB-promoting factor Mer2 in the wake of the replication fork ...[more]