Ontology highlight
ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC4142293 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gao Shan S Hein San S Dagnæs-Hansen Frederik F Weyer Kathrin K Yang Chuanxu C Nielsen Rikke R Christensen Erik I EI Fenton Robert A RA Kjems Jørgen J
Theranostics 20140813 10
RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered intravenously. Here we confirm by 2D and 3D bioimaging that chitosan formulated siRNA is retained in the kidney for more than 48 hours where it accumulates in proximal tubule epith ...[more]