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Engineered T cells for cancer therapy.


ABSTRACT: It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this focused research review.

SUBMITTER: June CH 

PROVIDER: S-EPMC4142345 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Engineered T cells for cancer therapy.

June Carl H CH   Maus Marcela V MV   Plesa Gabriela G   Johnson Laura A LA   Zhao Yangbing Y   Levine Bruce L BL   Grupp Stephan A SA   Porter David L DL  

Cancer immunology, immunotherapy : CII 20140619 9


It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this focused re  ...[more]

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