Evaluation and integration of genetic signature for prediction risk of nasopharyngeal carcinoma in Southern China.

ABSTRACT:

Unlabelled

Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC).

Results

The reported associations between ITGA9 variants and NPC were not replicated. Multiple loci of GABBR1, HLA-F

SUBMITTER: Guo X 

PROVIDER: S-EPMC4142549 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature