Ontology highlight
ABSTRACT:
SUBMITTER: Gou J
PROVIDER: S-EPMC4142613 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Gou Jia J Edelstein-Keshet Leah L Allard Jun J
Molecular biology of the cell 20140618 16
In many cellular contexts, cargo is transported bidirectionally along microtubule bundles by dynein and kinesin-family motors. Upstream factors influence how individual cargoes are locally regulated, as well as how long-range transport is regulated at the whole-cell scale. Although the details of local, single-cargo bidirectional switching have been extensively studied, it remains to be elucidated how this results in cell-scale spatial organization. Here we develop a mathematical model of early ...[more]