Ontology highlight
ABSTRACT:
SUBMITTER: Behrens AN
PROVIDER: S-EPMC4142794 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Behrens Ann N AN Zierold Claudia C Shi Xiaozhong X Ren Yi Y Koyano-Nakagawa Naoko N Garry Daniel J DJ Martin Cindy M CM
Stem cells and development 20140617 17
Vasculogenesis/angiogenesis is one of the earliest processes that occurs during embryogenesis. ETV2 and SOX7 were previously shown to play a role in endothelial development; however, their mechanistic interaction has not been defined. In the present study, concomitant expression of Etv2 and Sox7 in endothelial progenitor cells was verified. ETV2 was shown to be a direct upstream regulator of Sox7 that binds to ETV2 binding elements in the Sox7 upstream regulatory region and activates transcripti ...[more]