Ontology highlight
ABSTRACT:
SUBMITTER: Rabe P
PROVIDER: S-EPMC4142847 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rabe Patrick P Klapschinski Tim A TA Brock Nelson L NL Citron Christian A CA D'Alvise Paul P Gram Lone L Dickschat Jeroen S JS
Beilstein journal of organic chemistry 20140806
Tropodithietic acid (TDA) is a structurally unique sulfur-containing antibiotic from the Roseobacter clade bacterium Phaeobacter inhibens DSM 17395 and a few other related species. We have synthesised several structural analogues of TDA and used them in bioactivity tests against Staphylococcus aureus and Vibrio anguillarum for a structure-activity relationship (SAR) study, revealing that the sulfur-free analogue of TDA, tropone-2-carboxylic acid, has an antibiotic activity that is even stronger ...[more]