Multimonth controlled small molecule release from biodegradable thin films.

ABSTRACT: Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity to vital organs typically caused by systemic administration and decreasing the need for medical intervention because of its long-lasting release. Also important is the ability to achieve high drug loadings in thin film coatings to allow incorporation of significant drug amounts on implant surfaces. Here we report a sustained release formulation for small molecules based on a soluble charged polymer-drug conjugate that is immobilized into nanoscale, conformal, layer-by-layer ass

SUBMITTER: Hsu BB 

PROVIDER: S-EPMC4143022 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature