Ontology highlight
ABSTRACT:
SUBMITTER: Guo A
PROVIDER: S-EPMC4143026 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Guo Ang A Zhang Xiaoying X Iyer Venkat Ramesh VR Chen Biyi B Zhang Caimei C Kutschke William J WJ Weiss Robert M RM Franzini-Armstrong Clara C Song Long-Sheng LS
Proceedings of the National Academy of Sciences of the United States of America 20140804 33
Heart failure is accompanied by a loss of the orderly disposition of transverse (T)-tubules and a decrease of their associations with the junctional sarcoplasmic reticulum (jSR). Junctophilin-2 (JP2) is a structural protein responsible for jSR/T-tubule docking. Animal models of cardiac stresses demonstrate that down-regulation of JP2 contributes to T-tubule disorganization, loss of excitation-contraction coupling, and heart failure development. Our objective was to determine whether JP2 overexpr ...[more]